Antiparasitic Drugs

Product Details:

• Drug Name: Praziquantel

• Strength: 600 mg per tablet

• Drug Class: Anthelmintic (anti-parasitic)

• Type: Isoquinoline-pyrazine derivative

• WHO Essential Medicine: Yes – widely used in deworming programs worldwide.

• Praziquantel increases calcium ion permeability in the parasite’s cell membranes.

• This leads to sustained contraction (spastic paralysis) of the worms.

• The paralyzed worms detach from host tissues, disintegrate, and are destroyed by the host’s immune system.

• Effective against trematodes (flukes) and cestodes (tapeworms).

Praziquantel 600 mg is used for treatment of:

1. Schistosomiasis (blood fluke infection) – Schistosoma haematobium, mansoni, japonicum, mekongi, intercalatum

2. Clonorchiasis (Clonorchis sinensis – Chinese liver fluke)

3. Opisthorchiasis (Opisthorchis viverrini)

4. Paragonimiasis (lung fluke)

5. Cestode (tapeworm) infections:

   • Taenia saginata (beef tapeworm)

   • Taenia solium (pork tapeworm)

   • Diphyllobothrium latum (fish tapeworm)

   • Hymenolepis nana (dwarf tapeworm)

6. Cysticercosis (neurocysticercosis) – as part of combination therapy with steroids and anticonvulsants.

7. Other fluke infections: Fasciolopsiasis, etc.

💊 Dosage is based on infection type and body weight.

• Usual adult dose: 20–25 mg/kg per dose, given 2–3 times in one day (depending on parasite).

• Example:

  • Schistosomiasis: 20 mg/kg × 2 doses in one day.

  • Clonorchiasis/Opisthorchiasis: 25 mg/kg × 3 doses in one day.

  • Tapeworm infections: Single dose of 5–10 mg/kg (except H. nana which may need 25 mg/kg).

👉 A 600 mg tablet is convenient for adult dosing since many regimens require multiple tablets in a single day.

• Absorption: Rapidly absorbed orally; bioavailability improved when taken with a fatty meal.

• Onset of action: Within hours.

• Peak plasma: 1–3 hours.

• Metabolism: Mainly in liver (CYP3A4).

• Half-life: 1–2.5 hours.

• Excretion: Urine and bile.

Most side effects are mild and short-lived:

• Abdominal pain, nausea, vomiting, diarrhea

• Headache, dizziness, drowsiness

• Low-grade fever, sweating

• Rash, itching (due to parasite die-off)

• Rare: arrhythmia, seizures (in neurocysticercosis, when many larvae die simultaneously)

• Not recommended for children <4 years (safety not well established).

• Pregnancy: Usually avoided in the first trimester, but WHO allows use in later pregnancy for schistosomiasis.

• Liver disease: Use cautiously (metabolized by liver).

• Neurocysticercosis: Always combined with corticosteroids (to prevent brain inflammation due to dying parasites).

• Should not be used in patients with ocular cysticercosis (can damage vision).

Additional Information:

• Production Capacity: 25000 Strips per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

• Generic name: Niclosamide

• Strength: 500 mg (per tablet)

• Class: Anthelmintic (anti-parasitic)

• Main use: Treatment of tapeworm (cestode) infections in humans.

• Niclosamide 500 mg (active ingredient)

• Oral tablet, usually to be chewed or swallowed after thorough chewing (sometimes crushed for children).

• Niclosamide works by inhibiting oxidative phosphorylation in tapeworms.

• This disrupts parasite’s energy metabolism → leads to paralysis and death of the worm.

• It primarily acts in the intestinal lumen (not absorbed well into bloodstream).

• Intestinal tapeworm infections, such as:

  • Taenia saginata (beef tapeworm)

  • Taenia solium (pork tapeworm)

  • Diphyllobothrium latum (fish tapeworm)

  • Hymenolepis nana (dwarf tapeworm)

⚠️ Not effective for roundworms or flukes → only for cestodes.

• Adults: 2 g as a single dose (i.e., 4 tablets of 500 mg).

• Children (above 6 years): 1 g (2 tablets).

• Children (2–6 years): 500 mg (1 tablet).

• Should be taken after a light meal, followed by a mild laxative after 2 hours (in some regimens) to help expel dead worms.

(Exact regimen may vary based on worm species and physician’s protocol.)

Generally well tolerated since poorly absorbed.

Common (mild):

• Nausea, vomiting

• Abdominal pain, diarrhea

• Dizziness, headache

Rare:

• Skin rash, itching

• Toxicity (extremely rare due to poor absorption)

• Hypersensitivity to Niclosamide

• Not recommended in pregnancy unless essential (safety not well established)

• Caution in children under 2 years

• Should ensure proper hygiene to prevent reinfection

• Niclosig 500

• Yomesan (older international brand)

• Other generics available in India from multiple manufacturers

Additional Information:

• Production Capacity: 25000 Strips per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

Hhmite Cream under that exact name. It is very likely that the name is a brand name or a regional/trade spelling. From the naming pattern and available trade usage, Hhmite Cream is generally known as a Permethrin-based topical anti-scabies/antiparasitic cream used for the treatment of scabies and sometimes lice infestation.

Here’s a detailed breakdown (based on the common formulation in India):

Category: Antiparasitic / Scabicidal topical preparation

Active Ingredient:

• Permethrin 5% w/w (most common strength)

Uses / Indications:

• Treatment of Scabies (infestation by Sarcoptes scabiei mites)

• Treatment and prophylaxis of Pediculosis (lice infestations)

• Sometimes used in demodicosis (mite-related skin conditions) under medical advice

Mechanism of Action:

• Permethrin is a synthetic pyrethroid.

• It works by paralyzing and killing mites and lice through interference with their sodium channel function in nerve cells.

• It also kills their eggs to a significant extent, reducing reinfestation.

Directions for Use:

• Usually applied topically to the whole body from the neck down (sometimes including scalp in children/elderly)

• Left on skin for 8–12 hours (often overnight), then washed off

• A second application after 7 days may be recommended to kill any newly hatched mites/lice

• Clothing, bedding, and towels should be washed in hot water to prevent reinfestation

Side Effects (generally mild and temporary):

• Burning, stinging, or itching on application site

• Redness or mild rash

• Rare allergic reaction

Precautions:

• For external use only

• Avoid contact with eyes, mouth, mucous membranes

• Safe in children >2 months, but infants should only use under doctor supervision

• Use in pregnancy and lactation is generally considered safe, but always confirm with a physician

Additional Information:

• Production Capacity: 25000 Piece per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

Albendazole 400 mg Tablet – Uses:

Albendazole is a broad-spectrum antiparasitic (anthelmintic) medicine used to kill and eliminate various intestinal and tissue worms. It works by preventing the worms from absorbing sugar (glucose), which causes them to lose energy and die.

1. Intestinal Worm Infections – Effective against:

   • Roundworms (Ascariasis)

   • Hookworms (Ancylostomiasis, Necatoriasis)

   • Whipworms (Trichuriasis)

   • Pinworms (Enterobiasis)

2. Tapeworm Infections

   • Taeniasis (Pork or Beef tapeworm)

   • Hymenolepiasis (Dwarf tapeworm)

3. Hydatid Disease (Echinococcosis)

   • Caused by Echinococcus granulosus; Albendazole helps reduce cysts in the liver, lungs, and other organs.

4. Neurocysticercosis

   • Brain infection caused by larval form of the pork tapeworm (Taenia solium). Albendazole helps kill the larvae and reduce neurological symptoms.

5. Giardiasis (in children)

   • Sometimes used as an alternative treatment for Giardia lamblia infection.

• Adults: 400 mg single dose (for most intestinal worm infections).

• Hydatid disease / Neurocysticercosis: Higher doses (e.g., 400 mg twice daily for several weeks) as directed by a physician.

Additional Information:

• Production Capacity: 25000 strips per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .