Eye Drop

Product Details:

BRIMONIDINE 0.2% Eye Drops are a prescription ophthalmic solution used primarily to reduce elevated intraocular pressure (IOP) in conditions like glaucoma or ocular hypertension.

🔬 Composition

• Active Ingredient: Brimonidine tartrate 0.2%

• Class: Alpha-2 adrenergic receptor agonist

🧠 Mechanism of Action

Brimonidine works by:

1. Decreasing aqueous humor production (the fluid inside the eye)

2. Increasing uveoscleral outflow (draining fluid out of the eye)

This dual action helps lower the pressure inside the eye, which is crucial in preventing optic nerve damage and vision loss, especially in open-angle glaucoma.

✅ Uses

• Primary Open-Angle Glaucoma

• Ocular Hypertension

• Sometimes used off-label for redness relief or neuroprotection in certain eye disorders

💧 How to Use

• Usually prescribed 1 drop in the affected eye(s) twice or thrice daily

• Wash hands before use

• Avoid touching the dropper tip to the eye or any surface

• Wait at least 5–10 minutes before using other eye drops

⚠️ Side Effects

Common:

• Eye dryness or redness

• Blurred vision

• Mild burning/stinging upon instillation

• Sensation of something in the eye

Less common but serious:

• Allergic conjunctivitis

• Eye inflammation or swelling

• Fatigue or drowsiness

• Dry mouth

• Headache

🚫 Precautions & Warnings

• Not for children under 2 years (risk of severe CNS depression)

• Use with caution in:

  • Depression

  • Cardiovascular diseases

  • Raynaud's disease

  • Low blood pressure

Avoid driving or operating heavy machinery if it causes drowsiness or blurred vision.

🔄 Drug Interactions

• CNS depressants (may enhance drowsiness)

• MAO inhibitors (contraindicated – may cause hypertensive crisis)

• Other antiglaucoma agents – should be combined only under medical supervision

🧊 Storage

• Store in a cool, dry place

• Avoid contamination – cap tightly after use

• Discard 30 days after opening

Let me know if you want this information summarized for patients or formatted for a product label.

Additional Information:

• Production Capacity: 25000 drops per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

Polymyxin B (5000 IU/ml) + Chloramphenicol (4 mg/ml)

Category: Combination antibiotic ophthalmic preparation (commonly available as eye/ear drops).

Main Uses

1. Eye Infections (Ophthalmic Use)

   • Bacterial conjunctivitis (redness, discharge, irritation caused by bacteria)

   • Keratitis (corneal infection)

   • Blepharitis (eyelid infection)

   • Post-surgical prophylaxis to prevent infection after eye operations

2. Ear Infections (Otic Use)

   • Otitis externa (outer ear canal infection, “swimmer’s ear”)

   • Sometimes used in chronic suppurative otitis media with discharge (if eardrum is not perforated)

How It Works

• Polymyxin B

  • A polypeptide antibiotic effective against Gram-negative bacteria (like Pseudomonas aeruginosa, E. coli, Klebsiella).

  • Disrupts bacterial cell membrane, leading to cell death.

• Chloramphenicol

  • A broad-spectrum antibiotic active against Gram-positive and Gram-negative bacteria.

  • Inhibits protein synthesis by binding to the 50S ribosomal subunit.

👉 Together, they provide broad-spectrum coverage against many bacterial eye/ear pathogens.

Not Effective For

• Viral infections (e.g., viral conjunctivitis)

• Fungal infections of eye/ear

Dosage & Administration

• Usually 1–2 drops into the affected eye/ear every 4–6 hours, as directed by a doctor.

• Duration: 7–10 days, depending on infection severity.

Side Effects

Local/common:

• Eye irritation, redness, stinging/burning sensation

• Blurred vision (temporary) after application

Rare but serious:

• Allergic reactions (swelling, itching, rash)

• Superinfection with resistant bacteria/fungi if used for too long

• Bone marrow suppression (very rare, with prolonged systemic use of chloramphenicol, but unlikely with local drops)

Precautions

• For topical use only (not for injection or oral use).

• Avoid if history of allergy to either drug.

• Use cautiously in pregnant/breastfeeding women (only if benefits outweigh risks).

• Do not use contact lenses during treatment of eye infection.

 

Additional Information:

• Production Capacity: 25000 Drops per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

Chloramphenicol 0.5% is a topical ophthalmic antibiotic preparation (eye drops or ointment) used to treat bacterial infections of the eye. It belongs to the class of broad-spectrum antibiotics and is effective against both Gram-positive and Gram-negative bacteria.

🔹 Composition & Form

• Active ingredient: Chloramphenicol 0.5% w/v (in solution) or 0.5% w/w (in ointment)

• Forms available: Eye drops (0.5%), Eye ointment (1%)

• Preservatives (like boric acid, phenylmercuric nitrate, etc.) may be present in some formulations.

🔹 Mechanism of Action

• Chloramphenicol binds to the 50S subunit of bacterial ribosomes.

• This inhibits protein synthesis, stopping bacterial growth.

• It is bacteriostatic at lower concentrations, but can be bactericidal at higher local concentrations in the eye.

🔹 Medical Uses

Chloramphenicol 0.5% is indicated for:

1. Bacterial Conjunctivitis (red, sticky eye caused by bacteria)

2. Keratitis (infection of cornea)

3. Blepharitis (infection/inflammation of eyelids)

4. Post-surgical prophylaxis against bacterial infection

5. Superficial ocular infections caused by susceptible organisms

⚠️ Not effective against viral (e.g. adenovirus) or fungal eye infections.

🔹 Dosage & Administration

• Eye Drops:

  • Instill 1 drop into the affected eye every 2–6 hours (depending on severity).

  • Once symptoms improve, frequency may be reduced.

• Eye Ointment:

  • Apply a thin film inside the lower eyelid 3–4 times daily.

  • Sometimes used at night with drops during the day.

• Treatment duration: Usually 5–7 days.

• Always wash hands before and after use.

• Do not touch the dropper tip to eye/skin to avoid contamination.

🔹 Side Effects

Common (usually mild & temporary):

• Stinging, burning, irritation after instillation

• Blurred vision for a short period

• Watery eyes

Serious (rare):

• Allergic reactions (swelling, itching, rash, breathing difficulty)

• Bone marrow suppression or aplastic anemia (extremely rare; more associated with systemic use but reported with topical use in rare cases)

• Secondary infections (if used long-term, may promote resistant bacteria or fungal overgrowth)

🔹 Contraindications & Precautions

• Do not use if allergic to chloramphenicol.

• Avoid in pregnancy & breastfeeding unless specifically prescribed.

• Should not be used in viral, fungal, or non-infectious eye conditions.

• Contact lens wearers: remove lenses before use and wait at least 15–20 minutes before reinserting.

• Prolonged use should be avoided → use only for the prescribed duration.

Additional Information:

• Production Capacity: 250000 dropd per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

Netarsudil 0.02% w/v Eye Drops are an advanced glaucoma medication used to reduce elevated intraocular pressure (IOP) in the eyes. It is a relatively newer Rho kinase inhibitor, offering a unique mechanism compared to traditional glaucoma drugs.

🔬 Composition

• Active Ingredient: Netarsudil mesylate equivalent to Netarsudil 0.02% w/v

• Class: Rho kinase (ROCK) inhibitor

🧠 Mechanism of Action

Netarsudil works by:

1. Increasing trabecular meshwork outflow – the main drainage pathway for aqueous humor (fluid in the eye)

2. Lowering episcleral venous pressure – reducing resistance to fluid drainage

3. Reducing aqueous humor production (to a lesser extent)

👉 Overall, it lowers IOP, which is crucial for managing open-angle glaucoma and ocular hypertension.

✅ Indications

• Primary Open-Angle Glaucoma

• Ocular Hypertension

• Can be used alone or in combination with other IOP-lowering agents

💧 Dosage & Administration

• Typically: One drop in the affected eye(s) once daily in the evening

• Avoid touching the tip of the dropper to any surface or the eye

• Do not use more than once daily (may reduce effectiveness or increase side effects)

⚠️ Side Effects

Common:

• Conjunctival hyperemia (eye redness) – seen in up to 50% of users

• Eye discomfort or irritation

• Corneal verticillata (harmless swirling patterns on the cornea)

• Tearing or dryness

• Blurred vision

Less Common:

• Eyelid redness or swelling

• Increased pigmentation of the eye (rare)

• Allergic reactions (itching, swelling, rash)

🚫 Precautions

• Use with caution in patients with:

  • Corneal disorders

  • Severe dry eye

• Safety in children under 18 not well established

• Contact lenses should be removed before application and reinserted after 15 minutes

💊 Drug Interactions

• No major systemic drug interactions, but avoid using multiple glaucoma drops without doctor’s advice

• If using other eye drops, space them at least 5–10 minutes apart

🧊 Storage

• Store at 2°C to 8°C (refrigerated) before opening

• Once opened, can be stored at room temperature (up to 25°C) for 6 weeks

• Protect from light and moisture

📌 Special Notes

• The redness it causes is not harmful, but may bother some patients cosmetically

• Offers a novel mechanism that complements prostaglandin analogs or beta-blockers

 

Additional Information:

• Production Capacity: 25000 Bottles per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

• Brimonidine tartrate is an alpha-2 adrenergic receptor agonist.

• Used as an ophthalmic solution (eye drop) for lowering intraocular pressure (IOP) in patients with glaucoma or ocular hypertension.

• 0.2% w/v means 0.2 g of brimonidine in 100 ml solution (2 mg/ml).

🔹 Mechanism of Action

• Stimulates alpha-2 adrenergic receptors in the eye.

• Results in:

  1. Decreased aqueous humor production (less fluid formed inside the eye).

  2. Increased uveoscleral outflow (better drainage of eye fluid).

• Net effect → reduced intraocular pressure (IOP).

🔹 Medical Uses

• Primary open-angle glaucoma.

• Ocular hypertension (raised IOP without optic nerve damage).

• Sometimes used in combination therapy with other anti-glaucoma drugs (like timolol, latanoprost, dorzolamide) if monotherapy isn’t sufficient.

🔹 Dosage & Administration

• Strength: 0.2% solution.

• Typical dose: 1 drop in the affected eye(s) 2–3 times daily (about 8–12 hours apart).

• Wash hands → Tilt head back → Instill drop → Close eye gently & press inner corner (punctal occlusion) for 1–2 minutes to reduce systemic absorption.

🔹 Onset & Duration

• Onset of action: within 1–2 hours.

• Peak effect: 2–3 hours.

• Duration: about 8–12 hours (why it’s dosed 2–3 times daily).

🔹 Side Effects

Local (eye-related):

• Eye redness, burning, stinging, itching.

• Dry eyes, blurred vision, tearing.

• Allergic conjunctivitis/eyelid reactions (can develop after weeks/months).

Systemic (due to absorption into blood):

• Dry mouth, drowsiness, fatigue.

• Headache, dizziness.

• Low blood pressure or slow heart rate (rare).

🔹 Contraindications & Precautions

• Infants & young children (<2 years): contraindicated (risk of severe CNS depression, apnea, coma).

• Caution in:

  • Cardiovascular disease (hypotension, heart block).

  • Severe depression.

  • Patients on monoamine oxidase inhibitors (MAOIs) or certain antidepressants (risk of interaction).

🔹 Drug Interactions

• CNS depressants (alcohol, sedatives) → may enhance drowsiness.

• Antihypertensives/cardiac glycosides → additive blood pressure/heart effects.

• MAO inhibitors → contraindicated (affects metabolism of brimonidine).

Product Details:

This medication is used to relieve dry, irritated eyes. Common causes for dry eyes include wind, sun, heating/air conditioning, computer use/reading, and certain medications.This product may contain 1 or more of the following ingredients: carboxymethylcellulose, dextran, glycerin, hypromellose, polyethylene glycol 400 (PEG 400), polysorbate, polyvinyl alcohol, povidone, or propylene glycol, among others.Eye lubricants keep the eye moist, help to protect the eye from injury and infection, and decrease symptoms of dry eyes such as burning, itching, and feeling as if something is in the eye.

Product Details:

Uses of Polymyxin B (5000 IU/ml) + Chloramphenicol (4 mg/ml):

This combination is a broad-spectrum antibiotic preparation, commonly used topically (as eye/ear drops or ointment) to treat external infections caused by bacteria. It acts by inhibiting bacterial growth and killing sensitive organisms.

🔹 Therapeutic Uses:

1. Eye Infections (Ophthalmic use)

   • Bacterial conjunctivitis (pink eye)

   • Blepharitis (eyelid inflammation)

   • Keratitis / Keratoconjunctivitis (infection of cornea or conjunctiva)

   • Post-operative eye infections prevention

2. Ear Infections (Otic use)

   • Otitis externa (outer ear infection or “swimmer’s ear”)

   • Bacterial ear discharge due to localized infection

3. Skin and Wound Infections (Topical forms)

   • Minor cuts, abrasions, burns, or ulcers infected with susceptible bacteria

   • Used in some antibiotic ointments or creams for local infection control

⚙️ How Each Component Works:

• Polymyxin B: Destroys the bacterial cell membrane — effective mainly against Gram-negative bacteria (e.g., Pseudomonas, E. coli).

• Chloramphenicol: Inhibits bacterial protein synthesis — active against both Gram-positive and Gram-negative bacteria, providing broad coverage.

⚠️ Important Notes:

• For external/local use only — not for injection or ingestion.

• Avoid prolonged use, as it can promote fungal growth or bacterial resistance.

• Do not use in viral or fungal eye/ear infections.

• Possible mild side effects: temporary stinging, redness, or irritation.

• Use under medical supervision, especially for children or eye applications.

Additional Information:

• Production Capacity: 25000 PIECE per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .