Ivermectin

Product Details:

Ivrea 1 Cream is a medicine used in the treatment of rosacea, which is an inflammatory condition that affects face. It helps in reducing the redness, swelling and pimples associated with rosacea.

Your doctor will explain how to use Ivrea 1 Cream and how much you need. Read the instructions that come with the medicine to make sure you use it correctly. It is applied to the affected areas of your face as directed by your doctor. Your skin should be clean, and dry before using it. Avoid getting it into your mouth, eyes, or inside the nose. Use it regularly and at the same time of each day to get the most benefit of the medicine.

Ivrea 1 Cream may cause burning, irritation, itching, and redness at the site of application. These are usually temporary and go away with time. However, if these effects persist or worsen, inform your doctor. Before using it, you should ask your doctor’s advice if you are pregnant or breastfeeding.

Additional Information:

• Production Capacity: 25000 Cream per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

Ivrea 1 Cream is a medicine used in the treatment of rosacea, which is an inflammatory condition that affects face. It helps in reducing the redness, swelling and pimples associated with rosacea.

Your doctor will explain how to use Ivrea 1 Cream and how much you need. Read the instructions that come with the medicine to make sure you use it correctly. It is applied to the affected areas of your face as directed by your doctor. Your skin should be clean, and dry before using it. Avoid getting it into your mouth, eyes, or inside the nose. Use it regularly and at the same time of each day to get the most benefit of the medicine.

Ivrea 1 Cream may cause burning, irritation, itching, and redness at the site of application. These are usually temporary and go away with time. However, if these effects persist or worsen, inform your doctor. Before using it, you should ask your doctor’s advice if you are pregnant or breastfeeding.

Additional Information:

• Production Capacity: 25000 TUBES PER MONTH
• Delivery Time: 2-5 DAYS
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

 

• Drug Name: Ivermectin (topical formulation)

• Strength: 1% w/w cream

• Drug Class: Antiparasitic & anti-inflammatory agent

• Form: White to off-white topical cream

• FDA Approval: Approved (2014 in the US) for rosacea treatment

Mechanism of Action

Ivermectin 1% cream works through dual actions:

1. Antiparasitic action

   • Kills Demodex mites, microscopic parasites that naturally live in hair follicles but are often overpopulated in rosacea patients.

   • It binds to glutamate-gated chloride channels in mites → paralysis & death.

2. Anti-inflammatory action

   • Reduces inflammatory lesions (papules and pustules) by lowering pro-inflammatory cytokines.

   • Helps calm redness and irritation in rosacea.

Indications (Uses)

Main approved and off-label uses:

1. Rosacea (papulopustular type) – FDA-approved indication.

   • Reduces pimples, bumps, and pustules associated with rosacea.

2. Off-label uses:

   • Demodicosis (overgrowth of Demodex mites)

   • Perioral dermatitis (sometimes)

   • Scabies (localized) – though usually oral ivermectin or permethrin cream is preferred.

Dosage & Application

• Standard adult regimen:

  • Apply a thin layer of ivermectin 1% cream to affected areas of the face once daily.

  • Spread evenly, avoiding eyes, lips, and mucous membranes.

  • Continue treatment for several weeks (improvement often seen in 2–4 weeks, with maximum results at 12 weeks).

• Duration: May be prescribed for long-term use in chronic rosacea.

Pharmacology

• Absorption: Minimal systemic absorption when applied topically → low risk of systemic side effects.

• Metabolism: If absorbed, metabolized in the liver (CYP3A4).

• Excretion: Mainly via feces.

Side Effects

Usually mild and localized:

• Skin burning or stinging after application

• Itching, dryness, or redness

• Skin irritation or worsening rosacea initially (rare, temporary)

• Very rare: hypersensitivity reaction

Precautions

• External use only – avoid contact with eyes, mouth, or open wounds.

• Pregnancy & breastfeeding: Limited human data; animal studies suggest low risk, but should only be used if prescribed.

• Children: Safety in those under 18 not well established.

• Should not be applied with occlusive dressings unless prescribed.

Additional Information:

• Production Capacity: 25000 Tubes per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

Ivermectin 1% Cream

Ivermectin 1% cream is a topical antiparasitic and anti-inflammatory medication used mainly for skin conditions caused by mites or inflammation.

Main Uses:

1. Rosacea (Inflammatory Lesions & Redness)

   • The most common use.

   • Reduces the inflammatory bumps, pimples, and redness associated with papulopustular rosacea.

   • Works by killing Demodex mites (tiny parasites on the skin) and reducing inflammation.

2. Demodicosis (Mite Infestation of Skin)

   • Treats skin irritation, itching, and folliculitis caused by Demodex mites, especially on the face, eyelashes, and scalp.

3. Scabies (in some off-label cases)

   • Occasionally used to relieve itching and kill mites when oral ivermectin or permethrin is not suitable.

4. Other Parasitic Skin Conditions (off-label)

   • Certain cases of cutaneous larva migrans or lice infestations may benefit under medical supervision.

How It Works:

• Kills mites and parasites by paralyzing and eliminating them.

• Also has anti-inflammatory properties, reducing redness, swelling, and irritation of the skin.

Application:

• Apply a thin layer once daily on affected areas (usually the face).

• Avoid contact with eyes, lips, and inside the mouth.

• Wash hands after applying.

Treatment Duration:

• Visible improvement usually seen in 2–4 weeks, but treatment may continue for up to 12–16 weeks depending on the condition.

Key Benefits:

• Reduces inflammation, redness, and bumps.

• Helps restore smoother, clearer skin.

• Usually well tolerated with minimal irritation.

 

Additional Information:

• Production Capacity: 25000 tubes per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

Ivermectin 24 mg tablet is a high-strength antiparasitic medication used to treat various parasitic infections caused by worms, mites, and insects. It belongs to the macrocyclic lactone class and works by paralyzing and killing parasites.

Ivermectin is typically available in 3 mg, 6 mg, and 12 mg tablets, but 24 mg formulations are used in severe or resistant infections, or for adult patients requiring higher doses based on body weight.

✅ Common Uses

Ivermectin 24 mg is prescribed for:

1. Human Use

• Strongyloidiasis (intestinal threadworm)

• Scabies (especially crusted or resistant cases)

• Onchocerciasis (river blindness)

• Lice infestation

• Filariasis (lymphatic)

• Off-label for COVID-19 (in some regions; not officially approved)

2. Weight-Based Dose

Usually given at 150–200 mcg/kg body weight
Example: For a person weighing 70–80 kg, a 24 mg tablet may be a single-dose treatment

⚙️ How It Works

Ivermectin binds to glutamate-gated chloride channels in the nerves and muscles of parasites. This causes:

• Paralysis of the parasite

• Disruption of nerve signaling

• Eventual death of the parasite

It does not harm human nerves because the drug does not cross the blood-brain barrier at normal doses.

💊 Dosage & Administration

• Route: Oral tablet

• Timing: Usually single dose taken on an empty stomach (1 hour before or 2 hours after food)

• May be repeated after 7–14 days depending on infection type

• Dosing must be weight-based – do not self-dose with high strength

⚠️ Precautions

• Not recommended in children under 15 kg or under 5 years of age

• Use with caution in:

  • Liver disease

  • Severe asthma

  • Pregnancy (especially 1st trimester)

• Avoid alcohol with the dose

• Take plenty of fluids to avoid dehydration

🧪 Side Effects

Common:

• Nausea, dizziness

• Diarrhea or mild abdominal pain

• Headache

• Fatigue

Less Common / Serious:

• Low blood pressure

• Itching or rash due to parasite die-off

• Blurred vision or swelling (rare)

• Allergic reaction (especially in heavy parasitic loads)

📋 Summary Table

Additional Information:

• Production Capacity: 25000 strips per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .

Product Details:

 

• Ivermectin is an antiparasitic drug (anthelmintic).

• Belongs to the class of macrocyclic lactones (derived from avermectins).

• Used in both humans and animals for treating parasitic infections.

• The 20 mg strength is a higher-dose oral tablet (standard human doses are often 3 mg, 6 mg, or 12 mg; 20 mg is used when higher weight-based dosing is required).

🔹 Mechanism of Action

• Binds to glutamate-gated chloride ion channels in nerve and muscle cells of parasites.

• Causes increased permeability to chloride ions → paralysis and death of the parasite.

• Selectively toxic to parasites, not humans, because humans lack these channels (drug does not cross the blood–brain barrier significantly at normal doses).

🔹 Medical Uses in Humans

1. Intestinal & tissue helminth infections:

   • Strongyloidiasis (threadworm infection).

   • Onchocerciasis (river blindness caused by Onchocerca volvulus).

   • Lymphatic filariasis (with albendazole/DEC in mass programs).

2. Ectoparasites (skin infestations):

   • Scabies (mites).

   • Pediculosis (head lice).

   • Cutaneous larva migrans.

3. Other investigational/expanded uses:

   • Rosacea (in topical form, ivermectin cream/gel 1%).

   • Has been studied for viral infections (but not a standard or recommended use).

🔹 Dosage & Administration

• Oral tablet, swallowed with water on an empty stomach.

• Dose is usually weight-based:

  • 150–200 mcg per kg body weight as a single dose (may repeat depending on infection).

  • Example: A 60 kg adult → ~12 mg; so a 20 mg tablet may be used for heavier patients or split dosing.

• Common regimens:

  • Onchocerciasis: 150 mcg/kg every 6–12 months.

  • Strongyloidiasis: single 200 mcg/kg dose (may repeat after 2 weeks).

  • Scabies: single dose repeated after 7–14 days.

🔹 Side Effects

Mild/temporary:

• Headache, dizziness.

• Nausea, diarrhea, abdominal pain.

• Fatigue, muscle aches.

Related to parasite die-off (Mazzotti reaction, esp. in onchocerciasis):

• Itching, rash, fever, swollen lymph nodes, eye redness.

Rare/serious:

• Hypotension.

• Seizures, confusion (especially if drug crosses BBB, rare).

• Allergic reactions.

🔹 Contraindications & Precautions

• Children <15 kg (safety not established).

• Pregnancy: generally avoided (though WHO allows in mass campaigns if benefits outweigh risks).

• Liver disease: caution (metabolized in liver).

• Meningitis or conditions that impair the blood–brain barrier (risk of neurotoxicity).

Additional Information:

• Production Capacity: 25000 Strips per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .