Naltrexone Tablet

Product Details:

Naltrexone HCL 1.5 mg Capsule is a very low-dose formulation of naltrexone hydrochloride, a synthetic opioid receptor antagonist. It is used in different dose ranges for very different purposes. 

General Pharmacology
Drug class: Opioid antagonist

• Mechanism of action:

  • It binds to mu (µ), kappa (κ), and delta (δ) opioid receptors in the brain.

  • At higher doses (50–100 mg), it blocks the euphoric and sedative effects of opioids and reduces alcohol craving.

  • At low doses (1–4.5 mg), it is thought to temporarily block opioid receptors, causing the body to upregulate endorphin and enkephalin production, which may have immune-modulating and anti-inflammatory effects.

• Standard dose (50 mg/day):

  • Approved use for alcohol dependence and opioid dependence.

• Low-Dose Naltrexone (LDN, 1–4.5 mg):

  • Not officially FDA-approved for these indications, but widely studied and prescribed off-label.

  • Used for chronic pain, autoimmune, and inflammatory conditions.

Your capsule (1.5 mg) clearly falls into the Low-Dose Naltrexone (LDN) category.

Although not officially approved, research and clinical practice suggest it may help in:

1. Autoimmune diseases: Multiple sclerosis (MS), Hashimoto’s thyroiditis, rheumatoid arthritis, lupus.

2. Chronic pain syndromes: Fibromyalgia, neuropathic pain, complex regional pain syndrome (CRPS).

3. Inflammatory bowel diseases: Crohn’s disease, ulcerative colitis.

4. Other conditions under study: Chronic fatigue syndrome (CFS/ME), psoriasis, certain cancers (as an adjunct), and even long COVID.

• Absorption: Good oral absorption.

• Onset: Within 1–2 hours.

• Half-life: ~4 hours, but biological effects can last longer due to endorphin upregulation.

• Metabolism: Mainly hepatic (liver).

• Excretion: Renal (urine).

Usually well tolerated, but possible:

• Sleep disturbance (vivid dreams, insomnia at first)

• Headache

• Gastrointestinal upset (nausea, abdominal cramps)

• Anxiety or irritability (rare)

Side effects tend to be mild and temporary.

• Should not be combined with opioid painkillers (e.g., morphine, oxycodone, codeine, tramadol), as it blocks their effect and can cause withdrawal.

• Caution in severe liver disease.

• Pregnant/lactating women: safety not fully established.

Additional Information:

• Production Capacity: 25000 Strips per month
• Delivery Time: 2-5 Days
• Packaging Details: ALL MEDICINES ARE WELL PACKED IN BROWN CARD BOX WITH THARMACOLE AND PLASTIC TO MAKE DECENT PACKING AND PREVENT FROM ANY TYPE OF PRODUCT DAMAGE .