Product Details:
| Minimum Order Quantity | 10 Strip |
| Strength | 75 mg |
| Packaging Type | Strips |
| Packaging Size | 10x10 |
| Brand | Indocap |
| Manufacturer | Jagsonpal Pharmaceuticals Ltd |
| Composition | Indomethacin (75mg) |
| Shelf Life | 24 months |
| Usage/Application | Rheumatoid arthritis |
Additional Information:
Product Details:
| Minimum Order Quantity | 10 Strip |
| Strength | 5 mg |
| Manufacturer | Cipla |
| Packaging Size | 10*10 Tablets |
| Packaging Type | Box |
| Composition | Tofacitinib 5mg |
| Shelf Life | 36 Months |
| Usage | Rheumatoid arthritis |
Tofacitinib is an oral immunomodulatory drug classified as a Janus kinase (JAK) inhibitor. It is primarily used to treat autoimmune diseases by reducing inflammation and immune system overactivity.
🔬 Basic InformationGeneric Name: Tofacitinib
Brand Names: Xeljanz, Jaknat, Tofajak, Tofakin, Tofawell
Strength: 5 mg tablet (also available in 10 mg, extended-release forms)
Drug Class: Janus kinase (JAK) inhibitor
Route: Oral
Prescription Required: Yes
Schedule: Prescription-only medicine in most countries
Tofacitinib is approved or used for treatment of several chronic autoimmune and inflammatory conditions:
| Condition | Indication |
|---|---|
| Rheumatoid arthritis (RA) | Moderate to severe cases unresponsive to methotrexate |
| Psoriatic arthritis | Used alone or with other DMARDs |
| Ulcerative colitis | Moderate to severe active UC |
| Ankylosing spondylitis (AS) | In some regions, for spinal inflammation |
| Alopecia areata (off-label) | Hair regrowth in autoimmune hair loss |
| Vitiligo (off-label) | Repigmentation therapy (with or without light treatment) |
Tofacitinib works by inhibiting Janus kinase enzymes (JAK1 and JAK3). These enzymes are involved in the signaling of cytokines that regulate:
Immune response
Inflammation
Cell growth and differentiation
By blocking these signals, tofacitinib helps reduce inflammation and halt immune attacks on the body’s own tissues.
💊 Dosage| Condition | Dose |
|---|---|
| Rheumatoid/Psoriatic arthritis | 5 mg twice daily |
| Ulcerative colitis (induction) | 10 mg twice daily for 8 weeks |
| Ulcerative colitis (maintenance) | 5–10 mg twice daily |
⚠️ Dose may be adjusted based on response, liver/kidney function, and other medications.
⚠️ Side Effects| Common (mild to moderate) | Serious (rare) |
|---|---|
| Headache, fatigue | Blood clots (DVT, PE) |
| Nausea, diarrhea | Serious infections (TB, herpes zoster) |
| High cholesterol | Liver damage |
| Upper respiratory infections | Increased risk of cancer (long-term use) |
| Elevated liver enzymes | GI perforation (rare) |
Active serious infections (e.g. tuberculosis)
History of blood clots, heart problems, or stroke
Caution in elderly patients
Monitor in chronic liver disease or renal impairment
May interact with:
Ketoconazole, Rifampicin
Other immunosuppressants (increased risk of infection)
Additional Information: