Product Details:
Brand Name | Covimectin |
Dosage | 12 mg OD |
Strength | 12mg |
Packaging Size | 10*10 Box (100 Tablets) |
Tablets in a Strip | 10 |
Manufacturer | Signature HAB |
Composition | Ivermectin |
Usages | Parasitic Infection Covid 19 |
Ivermectin has exhibited antiviral activity against a wide range of RNA and some DNA viruses, for example, Zika, dengue, yellow fever, and others.
13 Caly et al
14 demonstrated specific action against SARS-CoV-2 in vitro with a suggested host-directed mechanism of action being the blocking of the nuclear import of viral proteins
14,15 that suppress normal immune responses. However, the necessary cell culture EC50 may not be achievable in vivo
.16 Other conjectured mechanisms include inhibition of SARS-CoV-2 3CLPro activity
17,18 (a protease essential for viral replication), a variety of anti-inflammatory effects,
19 and competitive
binding of ivermectin with the viral S protein as shown in multiple
in silico studies.
20 The latter would inhibit viral binding to ACE-2 receptors suppressing infection. Hemagglutination via viral binding to sialic acid receptors on erythrocytes is a recently proposed pathologic mechanism
21 that would be similarly disrupted. Both host-directed and virus-directed mechanisms have thus been proposed, the clinical mechanism may be multimodal, possibly dependent on disease stage, and a comprehensive review of mechanisms of action is warranted.